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Fuzi Guizhi Decoction granules
- Development stage
- Preclinical
- Lead developer
- The First Affiliated Hospital of Yunnan University of Chinese Medicine
- Administration
- Oral
01
Overview
Fuzi Guizhi Decoction granules is a Traditional Chinese Medicine (TCM) formulation being investigated as an adjunctive treatment for rheumatoid arthritis (RA). Developed by The Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, the decoction is specifically targeted at patients exhibiting the TCM pattern of kidney deficiency and cold coagulation. The formula is a combination of several botanical ingredients, most notably *Aconiti Lateralis Radix Praeparata* (Fuzi) and *Cinnamomi Ramulus* (Guizhi), which are traditionally used to warm the yang and dispel cold. In clinical trials, it is administered in granule form alongside standard disease-modifying antirheumatic drug (DMARD) therapy, such as methotrexate and folic acid, to evaluate its efficacy in reducing disease activity (DAS28 scores), alleviating joint pain, and improving the quality of life in RA patients.
- Other names
- Fuzi Guizhi DecoctionFuzi Guizhi Tang附子桂枝汤
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)MAPK3 (Mitogen-activated protein kinase 1)IL-6 (Interleukin 6)
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