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FV-LDP-D3-AE
- Development stage
- Preclinical
- Lead developer
- Chinese Academy of Medical Sciences Peking Union Medical College
- Modality
- Recombinant Proteins and Enzymes, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
FV-LDP-D3-AE is a recombinant antibody-drug conjugate designed for targeted cancer therapy. It consists of a single-chain variable fragment (scFv) of an anti-EGFR antibody, the apoprotein of lidamycin (LDP), and the third domain of human serum albumin (D3), to which the enediyne chromophore (AE) of lidamycin is conjugated. FV-LDP-D3-AE binds specifically to EGFR-overexpressing cancer cells, inhibits EGFR phosphorylation, downregulates IMPDH2 expression, induces apoptosis and DNA damage, causes G2/M cell cycle arrest, and results in mitochondrial damage. The drug enters cancer cells via intensive macropinocytosis, exhibiting high potency against esophageal, pancreatic, and colorectal cancers in preclinical models. Its mechanism combines EGFR-targeted delivery with the cytotoxic action of lidamycin enediyne[1][3][6].
- Brand names
- FV-LDP-D3-AEFV-LDP-D-3-AEFV-LDP-D 3-AE
- Other names
- FV-LDP-D3-AEFV-LDP-D-3-AEFV-LDP-D 3-AE
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)
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