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FZD4 siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Subcutaneous, Intrathecal, Intravitreal, Ophthalmic, Topical, Intratumoral, Intraperitoneal, Parenteral, Implant
01
Overview
FZD4 siRNA is a small interfering RNA (siRNA) designed to silence the expression of the Frizzled-4 (FZD4) receptor, a member of the Frizzled family of G protein-coupled receptors involved in Wnt signaling. In preclinical research, specifically within bladder cancer models, FZD4 siRNA is used to investigate the role of FZD4 in tumor cell motility, migration, and invasion. By mediating the sequence-specific degradation of FZD4 mRNA, the siRNA reduces FZD4 protein levels, thereby inhibiting downstream signaling pathways that contribute to oncogenic phenotypes. Studies have shown that knockdown of FZD4 via siRNA can significantly decrease the migration ability of human bladder cancer cells, identifying FZD4 as a potential therapeutic target in the context of tumor suppression.
- Other names
- Frizzled-4 siRNAFrizzled4 siRNAFrizzled 4 siRNAsiRNA targeting FZD4
02
Targets
FZD4 (Frizzled class receptor 4)
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