G-MTX

G-MTX is an experimental **peptide-drug conjugate nanoparticle** in which **methotrexate** is chemically grafted onto a **peptide dendrimer-based nanoparticle** for local treatment of inflammatory disease, particularly rheumatoid arthritis. Based on the provided publication, G-MTX is designed to enhance intracellular delivery of methotrexate after release in the acidic microenvironment of inflamed joints, leading to anti-inflammatory effects including reversal of macrophage polarization from M1 toward M2. It appears to be a preclinical research-stage nanomedicine rather than a marketed pharmaceutical product, and in the cited work it was incorporated into hyaluronic acid microparticles as part of the higher-order H-G-MTX delivery system for intra-articular administration in a collagen-induced arthritis rat model.

Other names

MTX-conjugated nanoparticlepeptide dendrimer-grafted methotrexate