G-NP

G-NP is an experimental nanoparticle-based RNA interference (RNAi) therapeutic designed to silence the expression of growth-regulated oncogene alpha (Gro-α), also known as CXCL1. Gro-α is a pro-inflammatory chemokine and oncogene that promotes tumor cell proliferation, migration, and angiogenesis, particularly in ovarian clear cell carcinoma. The G-NP formulation consists of siRNA molecules encapsulated within a nanoparticle carrier, which protects the genetic material from degradation and facilitates cellular uptake. In many research applications, the nanoparticle is further modified with a follicle-stimulating hormone (FSH) peptide (specifically FSH β 33-53) to target the follicle-stimulating hormone receptor (FSHR), which is highly expressed in ovarian cancer tissues. This targeted approach (often referred to as FSH-G-NP) aims to improve the delivery of the siRNA payload to malignant cells while reducing systemic toxicity. Preclinical studies have demonstrated that G-NP-mediated silencing of Gro-α can significantly inhibit tumor growth and enhance the sensitivity of cancer cells to other treatments.

Other names

Gro-alpha siRNA nanoparticleCXCL1 siRNA nanoparticleCXCL-1 siRNA nanoparticleCXCL 1 siRNA nanoparticleFSH-G-NP