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G03-52-01
- Development stage
- Phase 2
- Lead developer
- RESILIENCE
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intramuscular
01
Overview
**G03-52-01** is an investigational lyophilized, fixed-dose cocktail of six full-length human or humanized IgG1 monoclonal antibodies: three directed against botulinum neurotoxin serotype A and three directed against botulinum neurotoxin serotype B. The antibodies bind non-overlapping toxin epitopes, neutralizing the toxins and promoting their clearance; the product is being developed as a medical countermeasure for pre-exposure and potential post-exposure prophylaxis against botulism, including aerosolized exposure. It is composed of the three-antibody products NTM-1631 and NTM-1632 and has completed Phase 2 evaluation in healthy adults following intramuscular administration. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC13211578/))
- Other names
- anti-botulinum toxin antibody cocktailBoNT/A antibody cocktail
02
Targets
BoNT/A (Botulinum neurotoxin type A)BoNT/B (Botulinum neurotoxin type B)
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