G47ΔmADA1

G47ΔmADA1 is an oncolytic herpes simplex virus (oHSV) based on the G47Δ backbone, engineered to express a secreted, codon-optimized mouse adenosine deaminase isoform 1 (mADA1). G47Δ is a third-generation oHSV with deletions in the γ34.5 and ICP47 genes and an inactivation of the ICP6 gene, which enhances its safety and tumor-selective replication. By expressing mADA1, the virus targets the adenosine immunosuppressive pathway in the tumor microenvironment (TME) by converting extracellular adenosine (eADO) into inosine. This reduction in adenosine levels is intended to alleviate immunosuppression and enhance anti-tumor immune responses, particularly in glioblastoma (GBM). Preclinical studies in orthotopic murine glioblastoma models have demonstrated significant therapeutic efficacy and survival benefits compared to the parental G47Δ virus.

Other names

G47delta-mADA1G-47delta-mADA1G 47delta-mADA1mADA1-armed oHSVmADA-1-armed oHSVmADA 1-armed oHSV