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Drug intelligence / Profile preview
G5-AuNP-Gd-Trastuzumab
- Development stage
- Preclinical
- Lead developer
- Genentech
- Modality
- Nanoparticles → Drug Delivery Systems, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**G5-AuNP-Gd-Trastuzumab** is an experimental HER2-targeted bimodal CT/MRI contrast nanoparticle developed for imaging HER2-positive tumors. It consists of a generation-5 polyamidoamine dendrimer containing gold nanoparticles for X-ray computed-tomography contrast, gadolinium chelates for magnetic-resonance contrast, and surface-conjugated trastuzumab for selective binding to human epidermal growth factor receptor 2. In mouse tumor models, intravenous administration enhanced MRI signal and CT contrast in HER2-positive tumors and supported receptor-specific cellular binding and internalization. It is a preclinical imaging construct, not an approved therapeutic or marketed diagnostic product.
- Other names
- G5-AuNP-Gd-TrastuzumabG-5-AuNP-Gd-TrastuzumabG 5-AuNP-Gd-Trastuzumab
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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