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GA-Fudan University-pancreatic cancer
- Development stage
- Unknown
- Lead developer
- Fudan University
- Modality
- Small Molecules
- Administration
- Inhalation, Intravenous
01
Overview
GA-Fudan University-pancreatic cancer refers to the general anesthesia (GA) protocol utilized as a control arm in a multi-center randomized controlled trial (NCT01957527) led by Fudan University. This protocol is specifically evaluated for its impact on the prognosis and recovery of patients undergoing elective pancreaticoduodenectomy for pancreatic cancer. In this clinical context, general anesthesia is maintained using the volatile anesthetic sevoflurane via inhalation and the synthetic opioid analgesic sufentanil via intravenous infusion, often supplemented with muscle relaxants. The study compares this standard general anesthesia and patient-controlled intravenous analgesia (PCIA) against a combination of general and epidural anesthesia (GEA) to determine effects on overall survival, disease-free survival, and neuroendocrine stress responses in pancreatic cancer patients.
- Other names
- General AnesthesiaGA-Fudan University-pancreatic cancer
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)GABAA (Gamma-aminobutyric acid receptor)MOR (Mu opioid receptor)
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