Ga-OncoFAP

Ga-OncoFAP (also known as 68Ga-OncoFAP or [68Ga]Ga-DOTAGA-OncoFAP) is a small molecule radiotracer designed for PET imaging of solid tumors. It consists of an ultra-high-affinity ligand (OncoFAP) targeting the Fibroblast Activation Protein (FAP), which is overexpressed in more than 90% of epithelial cancers—including breast, colorectal, ovarian, lung, skin, prostate and pancreatic cancers as well as some soft tissue and bone sarcomas. The molecule includes a DOTAGA chelator for labeling with Gallium-68 (^68^Ga). Its mechanism involves highly selective binding to FAP on cancer-associated fibroblasts within the tumor microenvironment. This enables non-invasive detection and staging of FAP-positive tumors via PET/CT imaging. Preclinical and early clinical studies have demonstrated rapid tumor accumulation with low uptake in healthy organs—especially kidneys—and high selectivity for malignant tissue. A Phase I clinical trial has been completed in patients with advanced solid tumors[2][4][5][6][7][8][9].

Brand names

Ga-OncoFAP

Other names

OncoFAP-68GaOncoFAP68GaOncoFAP 68Ga[68Ga]Ga-DOTAGA-OncoFAP