Drug intelligence / Profile preview

GABA-rich rice bran fermented by Lactobacillus fermentum

Development stage
Preclinical
Modality
Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

GABA-rich rice bran fermented by Lactobacillus fermentum is a naturally-derived functional food or nutraceutical produced through the fermentation of rice bran with the probiotic bacteria *Lactobacillus fermentum*. This process enriches the product with the active ingredient gamma-aminobutyric acid (GABA). It has been investigated in academic research for its potential therapeutic applications, including anti-inflammatory and anti-cancer properties. Its anti-inflammatory effects are attributed to the suppression of TLR4-MAPK/NF-κB signaling cascades in macrophages. [14] Its anti-cancer potential, particularly in breast cancer, is linked to the downregulation of matrix metalloproteinase (MMP)-2 and MMP-9, which leads to cell cycle arrest and the induction of apoptosis. [15, 16] It is considered an academic research compound without a specific pharmaceutical developer or brand name. [15]

Other names
GCPGEPGABA-containing product from Lactobacillus fermentum-fermented rice branGABA-enriched product from Lactobacillus fermentum-fermented rice bran solution
02

Targets

BAX (Apoptosis regulator BAX)TLR4 (Toll-like receptor 4)MMP9 (Matrix metalloproteinase-9)NF-κBMMP2 (Matrix metalloproteinase-2)CASP9 (Caspase-9)CASP8 (Caspase-8)

Beyond the preview

Go deeper on GABA-rich rice bran fermented by Lactobacillus fermentum.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on GABA-rich rice bran fermented by Lactobacillus fermentum.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call