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Gabalyf Gel
- Development stage
- Unknown
- Lead developer
- Lyf Healthcare
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Gabalyf Gel is a topical analgesic formulation developed by Lyf Healthcare for the management of musculoskeletal pain. It is a triple-combination product containing gabapentin, lidocaine hydrochloride, and baclofen. Lidocaine acts as a local anesthetic by blocking sodium channels to prevent pain signal transmission. Gabapentin targets the alpha2delta subunit of voltage-gated calcium channels to modulate neuronal excitability, while baclofen serves as a GABAB receptor agonist to provide muscle relaxation. Although primarily known for their systemic effects, this topical formulation is designed for localized pain relief with reduced systemic absorption. It is currently approved and marketed in India.
- Brand names
- Gabalyf Gel
- Other names
- Gabapentin + Lidocaine Hydrochloride + Baclofen gelGabapentin + Lidocaine + Baclofen topical gel
02
Targets
GABA-B (Gamma-aminobutyric acid receptor type B)NaV (Voltage-gated sodium channels)α2δ (Voltage-gated calcium channel alpha-2-delta subunit)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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