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gabapentin + acetaminophen + ondansetron
- Development stage
- Unknown
- Lead developer
- Norman A. Brest
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
"Alternate Management" refers to a specific multimodal postoperative recovery protocol evaluated in clinical trials (such as NCT02441309) for patients undergoing cesarean sections. This regimen, investigated by researchers including Dr. Norman A. Brest, is designed as an alternative to the standard of care to reduce narcotic consumption and accelerate the return of bowel function. The protocol involves the preoperative administration of three distinct pharmaceutical agents: gabapentin, acetaminophen, and ondansetron. Gabapentin serves as an analgesic and anticonvulsant that modulates voltage-gated calcium channels; acetaminophen provides non-opioid analgesia and antipyresis; and ondansetron is a 5-HT3 receptor antagonist used to prevent postoperative nausea and vomiting (PONV). This combination is part of an Enhanced Recovery After Surgery (ERAS) strategy aimed at improving surgical outcomes and patient satisfaction.
- Other names
- Alternate ManagementAlternate Recovery ProtocolAlternate Management Protocol
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)HTR3A (5-hydroxytryptamine receptor 3A)PGHS-1 (Prostaglandin G/H Synthase 1)CACNA2D2 (α2δ-2)
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