gabapentin + thiamine + cyanocobalamin

F0434 is a Merck KGaA fixed-dose oral combination of **gabapentin**, **thiamine**, and **cyanocobalamin** developed for neuropathic pain associated with diabetic peripheral neuropathy. Gabapentin binds voltage-dependent calcium-channel alpha-2/delta auxiliary subunits, reducing excitatory neurotransmission, while thiamine and cyanocobalamin provide B-vitamin support relevant to peripheral nerve metabolism and myelin function. The F0434-labelled Phase 3 trial in chronic distal diabetic polyneuropathy was completed; the trial record's brief summary inconsistently calls the product \"F0343,\" but its official title and intervention identify F0434. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01263132))

Brand names

GavindoGavindo N

Other names

gabapentin + vitamin Bgabapentin/B-complex