Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
gabapentin + tramadol
- Development stage
- Unknown
- Lead developer
- Southwest Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
gabapentin + tramadol is a combination pharmacological regimen investigated for the conservative management of symptomatic sacral perineurial cysts, also known as Tarlov cysts. This combination therapy utilizes two distinct mechanisms to address chronic neuropathic and nociceptive pain. Gabapentin is a gabapentinoid that binds to the α2δ-1 subunit of voltage-gated calcium channels, leading to a reduction in the release of excitatory neurotransmitters. Tramadol is a centrally acting analgesic that functions as a weak agonist at the μ-opioid receptor and simultaneously inhibits the reuptake of norepinephrine and serotonin, thereby enhancing descending inhibitory pain pathways. The specific use of this combination for Tarlov cysts has been evaluated in clinical trials led by Southwest Hospital in China, comparing its efficacy against surgical interventions like microscopic tamponade.
- Other names
- gabapentin and tramadol
02
Targets
SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)MOR (Mu opioid receptor)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
Beyond the preview
Go deeper on gabapentin + tramadol.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on gabapentin + tramadol.