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Gabatop
- Development stage
- Unknown
- Lead developer
- Mac Millon Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Gabatop** is an oral fixed-dose neuropathic-pain product family marketed by Mac Millon Pharmaceuticals. Available Gabatop presentations include gabapentin combined with either nortriptyline or methylcobalamin; therefore, the unqualified name does not uniquely specify one invariant active-ingredient combination. Gabapentin binds the alpha-2/delta auxiliary subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release and neuropathic pain signaling. Nortriptyline inhibits norepinephrine and serotonin reuptake and can provide adjuvant analgesia, while methylcobalamin is an active vitamin B12 form used to support neuronal function and myelin maintenance. Gabatop products are used for neuropathic pain.
- Brand names
- Gabatop
02
Targets
NET (Norepinephrine Transporter)MTR (Methionine synthase)SERT (Sodium-dependent serotonin transporter)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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