Drug intelligence / Profile preview

Gabawell Gel

Development stage
Unknown
Lead developer
Primus Remedies
Modality
Small Molecules
Administration
Topical
01

Overview

Gabawell Gel is a topical combination medication containing the muscle relaxant baclofen (2% w/w), the anticonvulsant gabapentin (6% w/w), and the local anesthetic lidocaine (5% w/w). Developed and marketed by Primus Remedies, it is formulated as a gel for the localized management of neuropathic pain, particularly diabetic neuropathy, post-herpetic neuralgia, and associated muscle spasms or joint discomfort. By delivering the active ingredients directly to the site of pain, Gabawell Gel provides targeted relief with minimal systemic absorption and side effects. Lidocaine acts by blocking voltage-gated sodium channels to prevent pain signal transmission, gabapentin binds to voltage-gated calcium channels to reduce the release of excitatory neurotransmitters, and baclofen acts as a GABA-B receptor agonist to reduce nerve excitability and alleviate muscle spasms.

Brand names
Gabawell Gel
Other names
baclofen + gabapentin + lidocainebaclofen + gabapentin + lidocaine hydrochloridegabapentin + lidocaine + baclofen
02

Targets

CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)CACNA2D2 (Voltage-gated calcium channel subunit alpha-2/delta-2)GABA-B (Gamma-aminobutyric acid receptor type B)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)SCN10A (Sodium channel protein type X alpha subunit)SCN11A (NaV1.9)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)SCN3A (Sodium channel protein type 3 subunit alpha)SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)SCN5A (Sodium channel protein type 5 subunit alpha)SCN8A (NaV1.6)SCN9A (Sodium channel protein type 9 subunit alpha)α2δ (Voltage-gated calcium channel alpha-2-delta subunit)

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