gadolinium-University of Florida

Gadolinium-University of Florida refers to the gadolinium-based contrast agents (GBCAs), specifically Magnevist (gadopentetate dimeglumine) and Dotarem (gadoterate meglumine), utilized as diagnostic tools in the University of Florida's IMPRESS-C (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults) study. In this clinical research context, these agents are not used for therapeutic purposes but are administered intravenously to measure the glomerular filtration rate (GFR) and assess long-term renal function in pediatric survivors of sepsis-associated acute kidney injury (sAKI). Gadolinium acts as a paramagnetic contrast medium that enhances signal intensity in magnetic resonance imaging (MRI) and allows for the clearance-based calculation of kidney function. The study evaluates the long-term renal and cardiovascular consequences of sepsis in children, using these agents to identify unrecognized impairment in kidney and endothelial function.

Brand names

MagnevistDotarem

Other names

gadopentetate dimegluminegadoterate megluminegadolinium-based contrast agentGBCAgadolinium (GD)-diethylene-triamine-pentaacetic acid-bis-oleate