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Gag Plus is a fixed-dose combination analgesic and anti-inflammatory medication marketed by Kaiser Pharmaceutical. It contains aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class, and paracetamol (acetaminophen). Aceclofenac acts by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are responsible for the production of prostaglandins that mediate pain, fever, and inflammation. Paracetamol complements this action by providing central analgesic and antipyretic effects, likely through the inhibition of prostaglandin synthesis in the central nervous system. Gag Plus is indicated for the management of acute pain and chronic inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
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