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GAIA-124

Development stage: Preclinical
Lead developer: GAIA BioMedicine
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies

Overview

GAIA-124 is a preclinical-stage, antibody-armed NK-like cell therapy being developed by GAIA BioMedicine Inc. for the treatment of undisclosed solid tumors. The therapy is based on the company's proprietary GAIA-102 platform, which consists of highly cytotoxic NK-like cells expanded from peripheral blood mononuclear cells (PBMCs). GAIA-124 is specifically engineered by "arming" these NK-like cells with an antibody directed against an undisclosed tumor-associated antigen, referred to as Target D. This modification is intended to enhance the specificity of the cell therapy, allowing the NK-like cells to recognize and eliminate tumor cells expressing the target antigen through antibody-mediated targeting and subsequent cell-mediated cytotoxicity.

Other names: GAIA-124 (antibody-armed)

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