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GAIA-125

Development stage: Preclinical
Lead developer: GAIA BioMedicine
Modality: CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

GAIA-125 is an antibody-armed natural killer (NK)-like cell therapy currently in preclinical development by GAIA BioMedicine Inc. The therapy is built upon the company's proprietary GAIA-102 platform, which utilizes highly activated and expanded NK-like cells derived from healthy donor peripheral blood. GAIA-125 is specifically engineered by arming these NK-like cells with a monoclonal antibody directed against an undisclosed tumor-associated antigen, referred to as Target E. This approach is designed to leverage the innate cytotoxic potential of NK cells and enhance their specificity through antibody-mediated targeting, allowing the cells to more effectively identify and eliminate tumor cells expressing the specific target antigen.

Other names: GAIA-125 (antibody-armed)

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