GALK1 siRNA

GALK1 siRNA is a small interfering RNA designed to silence the expression of the Galactokinase 1 (GALK1) gene. GALK1 is a key enzyme in the Leloir pathway, responsible for the initial step of galactose metabolism by phosphorylating galactose to galactose-1-phosphate. In the context of bladder cancer, GALK1 is often overexpressed and associated with advanced disease stages and poor prognosis. By abrogating GALK1 expression, this siRNA inhibits cancer cell proliferation, induces G1 and G2/M cell cycle arrest, and triggers apoptosis. Furthermore, GALK1 knockdown has been shown to increase mitochondrial reactive oxygen species (ROS) production and sensitize bladder cancer cells to chemotherapeutic agents like cisplatin and gemcitabine, suggesting its potential as a therapeutic target for metabolic reprogramming-based cancer treatments.

Other names

siRNA targeting GALK1GALK1-targeting siRNAGALK-1-targeting siRNAGALK 1-targeting siRNA