gallamine triethiodide

Gallamine triethiodide is a synthetic nondepolarizing neuromuscular blocking drug that was historically used as an adjunct to anesthesia to induce skeletal muscle relaxation during surgical procedures. It acts primarily by competitively binding to nicotinic acetylcholine receptor sites at the neuromuscular junction, thereby blocking the action of acetylcholine and preventing muscle contraction. Gallamine also exhibits antagonistic activity at muscarinic acetylcholine receptor M2, particularly affecting the cardiac vagus nerve, which can result in tachycardia and occasionally hypertension. The drug was developed by Daniel Bovet in 1947 and marketed under the brand name Flaxedil but has since been discontinued in many countries due to the availability of newer agents with improved safety profiles[1][2][5][7].

Brand names

Flaxedil

Other names

gallamine triethiodidegallamine