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gallic acid
- Development stage
- Preclinical
- Lead developer
- Kao
- Modality
- Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Gallic acid is a natural phenolic compound classified as a trihydroxybenzoic acid. It is widely found in plants, fruits, nuts, tea, and wine. Gallic acid exhibits several pharmacological properties including antioxidant, anti-inflammatory (primarily via inhibition of Mitogen-activated protein kinase signaling pathway and Nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway), antimicrobial, and antineoplastic effects. It has demonstrated therapeutic potential in preclinical models for gastrointestinal disorders, neuropsychological conditions (such as neuroprotection), metabolic diseases (including anti-obesity effects), cardiovascular diseases, and cancer by modulating cell cycle proteins and inducing apoptosis in cancer cells. Most evidence for its efficacy comes from cellular or animal studies; robust clinical data in humans are lacking[1][6][8].
- Other names
- 3,4,5-trihydroxybenzoic acid
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)F2 (Thrombin)CASP3 (Caspase-3)SELP (P-selectin)nsp7 (SARS-CoV-2 non-structural protein 7)LYZ (Lysozyme C)CASP7 (Caspase-7)RK (Ribokinase)JUN (Transcription factor Jun)PRKCA (Protein kinase C alpha)
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