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Drug intelligence / Profile preview
gallium 68 macroaggregated albumin
- Development stage
- Phase 3
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
- Administration
- Intravenous
01
Overview
Gallium 68 macroaggregated albumin (68Ga-MAA) is a radiopharmaceutical used for diagnostic imaging, particularly for lung perfusion studies using Positron Emission Tomography (PET). It consists of macroaggregated human serum albumin particles labeled with the positron-emitting radioisotope gallium-68. The particles become trapped in the first capillary bed encountered after intravenous injection, creating a temporary blockade of terminal arterioles/capillaries in the lung, allowing for visualization of pulmonary blood flow. 68Ga-MAA can be prepared from commercially available kits originally designed for technetium-99m labeling of MAA. The labeling process typically involves heating at optimal temperatures (around 90°C) to achieve high radiochemical purity. 68Ga-MAA has also been investigated for use in Selective Internal Radiation Therapy (SIRT) dosimetry and treatment planning.
- Other names
- 68Ga-MAAgallium 68 macro-aggregated albumingallium68 macro-aggregated albumingallium-68 macro-aggregated albumin[68Ga]Ga-MAA
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