Drug intelligence / Profile preview

gallium-68 NOTA

Development stage: Unknown
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
Administration: Intravenous, Oral

Overview

Gallium-68 NOTA (68Ga-NOTA) is a radiometal-chelator complex consisting of the positron-emitting radionuclide gallium-68 (^68Ga) coordinated by the macrocyclic chelating agent 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA). Due to the high thermodynamic stability and rapid labeling kinetics of the gallium-68 NOTA complex, it is widely utilized in radiochemistry and molecular imaging. Standalone 68Ga-NOTA has been investigated as a positron emission tomography (PET) tracer for the assessment of glomerular filtration rate (GFR) and gastric emptying. More commonly, NOTA serves as a bifunctional chelator conjugated to various targeting vectors (such as peptides, antibodies, or small molecules) to develop target-specific diagnostic radiopharmaceuticals (e.g., 68Ga-NOTA-hGZP, 68Ga-NOTA-AE105, and 68Ga-NOTA-exendin-4) for oncology and other clinical applications.

Other names: 68Ga-NOTA[68Ga]Ga-NOTAgallium-68-NOTAgallium68-NOTAgallium 68-NOTA

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