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gallium-68 triacetylfusarinine C
- Development stage
- Unknown
- Lead developer
- Palacky University Olomouc
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
Gallium-68 triacetylfusarinine C (68Ga-TAFC) is a radiolabeled siderophore-based diagnostic imaging agent developed for the detection of invasive pulmonary aspergillosis (IPA) and other invasive Aspergillus infections. Triacetylfusarinine C (TAFC) is the primary extracellular siderophore secreted by the opportunistic fungal pathogen *Aspergillus fumigatus* to scavenge iron from the host environment. By replacing the iron in TAFC with the positron-emitting radionuclide gallium-68, the tracer specifically targets and binds to the fungal siderophore transporter MirB, which is highly upregulated during active infection. This allows for highly sensitive and specific non-invasive localization of fungal lesions using positron emission tomography/computed tomography (PET/CT) imaging, with rapid renal clearance and minimal background uptake in healthy tissues.
- Other names
- 68Ga-triacetylfusarinine Cdesferri-triacetylfusarinine C gallium-68gallium (68Ga) triacetylfusarinine C
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