Drug intelligence / Profile preview

gallium chloride Ga-67

Development stage
Approved
Lead developer
GE Healthcare
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Gallium chloride Ga-67 is a radioactive isotope of gallium used primarily as a diagnostic radiopharmaceutical. It is typically complexed with sodium citrate to form gallium citrate Ga 67 for intravenous administration. After injection, it accumulates in certain viable primary and metastatic tumors as well as sites of acute inflammation, allowing for scintigraphic imaging. The exact mechanism by which it localizes in these tissues is not fully understood but appears to involve accumulation in lysosomes and binding to soluble intracellular proteins within the target cells. Gallium chloride Ga-67 is cyclotron-produced and has a physical half-life of approximately 78 hours. Its main clinical indications are the detection and localization of Hodgkin's disease, lymphomas, bronchogenic carcinoma (lung cancer), and some acute inflammatory lesions[1][2][4][5][6].

Brand names
Neoscan
Other names
gallium citrate Ga 67gallium Ga-67gallium chloride ga-67
02

Targets

LTF (Lactoferrin)

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