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gallium Ga-68

Development stage: Unknown
Lead developer: Advanced Accelerator Applications
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Gallium Ga-68 is a positron-emitting radioisotope used as a diagnostic radiopharmaceutical component for Positron Emission Tomography (PET) imaging. It has a physical half-life of approximately 68 minutes and decays primarily (89%) by positron emission, which results in the production of 511 keV annihilation photons detectable by PET scanners. Gallium Ga-68 is typically produced via a Germanium-68/Gallium-68 generator, providing a convenient, cyclotron-independent source for clinical facilities. In clinical practice, the isotope is chemically conjugated to various targeting molecules, such as somatostatin receptor ligands (e.g., DOTATATE, DOTATOC) or prostate-specific membrane antigen (PSMA) inhibitors, to enable high-resolution diagnostic visualization of neuroendocrine tumors and prostate cancer.

Other names: gallium-68gallium68gallium 68Ga 68Ga68Ga-68radioactive gallium

Targets

SSTR5 (Somatostatin receptor 5)SSTR3 (Somatostatin receptor 3)PSMA (Prostate-specific membrane antigen)SSTR2 (Somatostatin receptor type 2)SSTR1 (Somatostatin Receptor Type 1)

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