gallium Ga-68 alfatide

68Ga-alfatide is a radiopharmaceutical PET imaging agent consisting of the positron-emitting radioisotope Gallium-68 conjugated to a dimeric cyclic RGD (Arg-Gly-Asp) peptide, alfatide (also known as PRGD2), via a NOTA chelator. It specifically targets integrin αvβ3, a cell surface receptor that is significantly overexpressed on activated endothelial cells during neoangiogenesis and on various tumor cells, including those in non-small cell lung cancer (NSCLC). By binding to these receptors, 68Ga-alfatide allows for the non-invasive visualization and quantification of angiogenesis and tumor proliferation using PET/CT imaging. Developed primarily by the Fourth Military Medical University in China, it has been extensively studied for its utility in diagnosing lung cancer, staging disease, and differentiating malignant lesions from inflammatory conditions such as pulmonary tuberculosis.

Other names

68Ga-NOTA-E[c(RGDyK)]2Gallium-68 alfatideGallium68 alfatideGallium 68 alfatide68Ga-labeled alfatide