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gallium Ga 68-edotreotide

Development stage: Approved
Lead developer: University of Iowa
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

Gallium Ga 68-edotreotide is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for the localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. It consists of an 8 amino acid peptide (edotreotide, also known as DOTATOC) bound to the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and labeled with the radioactive isotope gallium-68. The compound binds to somatostatin receptors, with higher affinity for somatostatin receptor type 2, where it emits beta particle radiation for detection by PET.

Brand names: Somakit TOC
Other names: Gallium Ga 68-dotatocGallium (68Ga) edotreotideGallium edotreotide Ga-68Gallium-68 (DOTA0-Phel-Tyr3)octreotideEdotreotide gallium Ga-68

Targets

SSTR5 (Somatostatin receptor 5)SSTR2 (Somatostatin receptor type 2)

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