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gallium Ga 68 N188

Development stage: Phase 1
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

Gallium Ga 68 N188 is a radiopharmaceutical composed of a nectin-4-targeting bicyclic peptide (N188) labeled with the positron-emitting radioisotope gallium-68. It is designed for use in PET/CT imaging to noninvasively quantify membranous nectin-4 expression in tumors. The agent binds specifically to nectin-4 (poliovirus receptor-like protein 4; PVRL4), an emerging biomarker overexpressed in several cancers including urothelial carcinoma, pancreatic cancer, intrahepatic cholangiocarcinoma, cervical cancer, and hepatocellular carcinoma. By visualizing and quantifying nectin-4 expression levels in vivo, [68Ga]N188 can help stratify patients for therapies targeting nectin-4 (such as enfortumab vedotin) and may assist with staging or restaging disease. Preclinical and clinical studies have demonstrated high affinity for nectin-4 and favorable pharmacokinetics and safety profiles[1][2][5][4].

Other names: gallium Ga-68 N188[^68Ga]N188

Targets

PVRL4 (Nectin cell adhesion molecule 4)

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