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gallium Ga 68 PSMA-11
- Development stage
- Unknown
- Lead developer
- University of California
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Gallium Ga 68 PSMA-11 is a radiopharmaceutical diagnostic imaging agent consisting of the positron-emitting radionuclide gallium-68 complexed with PSMA-11 (also known as HBED-CC), a small molecule ligand that targets prostate-specific membrane antigen (PSMA). While PSMA is highly expressed in prostate cancer cells, it is also found in the neovasculature of various other solid tumors, including thyroid cancer. The University of California, San Francisco (UCSF) is evaluating this agent for PET/MRI imaging to improve the diagnosis and staging of aggressive or radioiodine-refractory thyroid cancers. By binding to PSMA expressed in the tumor microvasculature, the agent allows for high-resolution localization of disease spread that may be missed by conventional imaging modalities.
- Brand names
- ProstaMedix
- Other names
- Gallium-68 prostate specific membrane antigenGallium68 prostate specific membrane antigenGallium 68 prostate specific membrane antigenGallium Ga 68-labeled PSMA-1168Ga-labeled PSMA-11
02
Targets
PSMA (Prostate-specific membrane antigen)
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