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Gallium Ga 68-VMT02

Development stage: Phase 1
Lead developer: Perspective Therapeutics
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration: Intravenous

Overview

Gallium Ga 68-VMT02 is a radiopharmaceutical diagnostic agent used in positron emission tomography (PET) imaging to detect tumors that express the melanocortin-1 receptor (MC1R). Upon administration, the compound targets and binds to MC1R-expressing tumor cells—primarily melanoma—enabling their visualization via PET scans. MC1R is a G protein-coupled receptor expressed by melanocytes and involved in regulating skin and hair pigmentation. Gallium-68 is a positron-emitting isotope with a short half-life (~68 minutes), allowing for rapid imaging protocols with reduced radiation exposure. The agent serves as a companion diagnostic for identifying patients who may benefit from targeted radionuclide therapies against MC1R-positive tumors[1][3][7]. Developers: Viewpoint Molecular Targeting Manufacturers: Perspective Therapeutics

Other names: gallium Ga 68-VMT02[68Ga]-VMT02

Targets

MC1R (Melanocortin Type 1 Receptor)

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