galloflavin

Galloflavin is a **small molecule inhibitor of lactate dehydrogenase (LDH)**, specifically targeting LDH isoforms A (LDH-A) and B (LDH-B)[3][5]. It acts **by inhibiting glycolysis and ATP production**, exerting anti-proliferative effects in various cancer cell lines including breast, colorectal, pancreatic, and endometrial cancer[1][2][5]. Galloflavin demonstrates anticancer activity by blocking cell proliferation, migration, and invasion, reducing colony formation, and suppressing the expression of tumor-related proteins such as c-Myc and P21[1]. In inflammatory microenvironments, galloflavin also **directly targets and inhibits NLRP3**, an inflammasome component involved in cancer progression, reducing the expression of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β), and tumor growth in animal models[1].

Other names

galloflavin GF