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Gam-COVID-Vac (Gamaleya Center)
- Development stage
- Unknown
- Lead developer
- Gamaleya Center
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**Gam-COVID-Vac** is a two-component heterologous recombinant adenoviral-vector vaccine developed by the Gamaleya Research Institute of Epidemiology and Microbiology for prevention of COVID-19. Component I uses recombinant adenovirus type 26 and Component II uses recombinant adenovirus type 5; both vectors encode the full-length SARS-CoV-2 spike glycoprotein. Intramuscular prime-boost administration induces humoral and cellular immune responses directed against spike, supporting protection against SARS-CoV-2 infection and COVID-19. The vaccine is marketed as Sputnik V and was registered by the Russian Ministry of Health in August 2020; an interim Phase 3 analysis reported 91.6% efficacy against symptomatic COVID-19. ([thelancet.com](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2821%2900234-8/fulltext))
- Brand names
- Sputnik V
- Other names
- GamCovidVac
02
Targets
SARS-CoV-2 spike
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