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GAM501
- Development stage
- Phase 2
- Lead developer
- Tissue Repair Company
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Topical
01
Overview
**GAM501** is an investigational topical gene therapy formerly developed as **Excellarate** for chronic non-healing diabetic foot ulcers. It consists of a replication-defective adenovirus serotype 5 vector encoding human platelet-derived growth factor subunit B, formulated in a bovine type I collagen gel that acts as a local wound matrix. Local expression of platelet-derived growth factor-B is intended to stimulate platelet-derived growth factor receptor signaling, promoting recruitment and proliferation of fibroblasts and other reparative cells, angiogenesis, granulation tissue formation, and wound closure. GAM501 was evaluated in completed Phase 1/2 and Phase 2b clinical studies in neuropathic diabetic foot ulcers.
- Brand names
- Excellarate
- Other names
- Ad5PDGF-B/bovine type I collagen gelExcellarate
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)
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