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gamijinhae-tang
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gamijinhae-tang (GJHT) is a traditional Korean herbal medicine (Hanbang) formulation primarily utilized for the treatment of respiratory disorders characterized by inflammation and cough. As a modified version of the base Jinhae-tang formula, it typically consists of a complex mixture of medicinal herbs such as *Platycodon grandiflorum* and *Glycyrrhiza uralensis*. Pharmacological studies, including those using porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS) induced models, demonstrate that GJHT exerts potent anti-inflammatory effects. Its mechanism of action involves the suppression of pro-inflammatory mediators, specifically reducing the levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and inhibiting the recruitment of neutrophils into the airways. These properties suggest potential therapeutic utility in managing acute lung injury (ALI) and chronic obstructive pulmonary disease (COPD).
- Other names
- Gamijinhae-tangGJHT
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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