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Drug intelligence / Profile preview
gamma-cyclodextrin + midazolam
- Development stage
- Unknown
- Lead developer
- Primex Pharmaceuticals
- Modality
- Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
This drug is a combination of midazolam, a short-acting benzodiazepine with anxiolytic, sedative, amnestic, anticonvulsant, and muscle relaxant properties, and gamma-cyclodextrin (γ-cyclodextrin), an excipient used to enhance the solubility and stability of poorly water-soluble drugs. In this formulation (notably as ADV6209), midazolam is complexed with gamma-cyclodextrin in an oral solution or syrup form. The primary indication is for moderate sedation or premedication in pediatric anesthesia. Gamma-cyclodextrin acts as a carrier molecule that increases the aqueous solubility of midazolam without significantly altering its pharmacokinetics or pharmacodynamics[1][3]. This combination allows for improved taste masking and patient acceptance in children[2][3].
- Brand names
- ADV6209ADV-6209ADV 6209
- Other names
- gamma-cyclodextrin and midazolamγ-cyclodextrin + midazolamADV6209 oral solutionADV-6209 oral solutionADV 6209 oral solution
02
Targets
BZD site (GABA-A receptor benzodiazepine site)GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)
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