gamma-irradiated amniotic membrane

Gamma-irradiated amniotic membrane is a biological tissue graft derived from the human placenta, specifically the innermost layer of the fetal membranes. For therapeutic use, the tissue undergoes a preservation and sterilization process that involves decellularization, lyophilization (freeze-drying), and terminal sterilization using gamma radiation (typically at a dose of 25 kGy). This process ensures the material is sterile and shelf-stable for up to five years while maintaining the integrity of the extracellular matrix. It acts as a biological scaffold rich in collagen, fibronectin, and laminin, facilitating tissue regeneration, reducing inflammation, and providing structural support. In gynecological surgery, it is used as an alternative to synthetic mesh in procedures like posterior colporrhaphy to repair pelvic organ prolapse defects, such as rectoceles, by reinforcing the rectovaginal fascia.

Other names

gamma-irradiated sterilized freeze-dried amnion graftlyophilized amniotic membraneacellular amniotic membranesterilized lyophilized amniotic membrane