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gamma-polyglutamic acid-cisplatin complex
- Development stage
- Preclinical
- Lead developer
- Osaka University
- Modality
- Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intraperitoneal
01
Overview
gamma-polyglutamic acid-cisplatin complex is a polymer-drug conjugate formulation designed for the controlled release of the chemotherapeutic agent cisplatin. Developed by researchers at Osaka University, the formulation utilizes gamma-polyglutamic acid (gamma-PGA), a biodegradable and non-immunogenic polymer, to form a complex with cisplatin. This delivery system aims to provide a sustained release of the drug into the bloodstream, thereby reducing the peak plasma concentrations that contribute to acute renal toxicity (nephrotoxicity) while maintaining or enhancing anti-tumor efficacy. Preclinical studies in murine mesothelioma models have demonstrated that the complex maintains therapeutic blood levels longer than free cisplatin and shows superior anti-tumor activity with reduced adverse effects.
- Other names
- gamma-PGA/Cisplatin complexgamma-PGA-cisplatingamma-PGA + cisplatin
02
Targets
DNA
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