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Gan Mai Bai He Di Huang Tang
- Development stage
- Unknown
- Lead developer
- Hong Kong Baptist University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gan Mai Bai He Di Huang Tang (GMBHDHT) is a traditional Chinese medicine (TCM) herbal combination formula being investigated by Hong Kong Baptist University for the treatment of perimenopausal syndrome (PMS). The formula is specifically indicated for patients diagnosed with the Liver and Kidney Yin Deficiency syndrome pattern, which is characterized by symptoms such as hot flushes, night sweats, insomnia, and irritability. GMBHDHT is a hybrid decoction combining elements of Gan Mai Bai He Tang (a variation of the classical Gan Mai Da Zao Tang) and Di Huang Tang (typically based on Rehmannia glutinosa). In clinical trial settings, it is administered as water-soluble granules. The formula is part of a personalized medicine approach where TCM practitioners prescribe specific herbal combinations based on individual syndrome differentiation rather than a standardized fixed formula.
- Other names
- Gan Mai Bai He Tang + Di Huang TangGan Mai Bai He Di Hung TangGMBHDHT
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (5-hydroxytryptamine receptor 2A)ESR1 (ERα)
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