Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Gandou Fumu Granule
- Development stage
- Preclinical
- Lead developer
- First Affiliated Hospital of Anhui University of Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gandou Fumu Granule (肝豆扶木颗粒), also referred to as Gandou Fumu Decoction (肝豆扶木汤), is a traditional Chinese medicine (TCM) preparation primarily investigated for the treatment of Wilson's disease (hepatolenticular degeneration), particularly focusing on liver fibrosis and copper metabolism. It is composed of multiple herbal ingredients including Polygonum multiflorum, Lycium barbarum, Panax notoginseng, Smilax glabra, Paeonia lactiflora, Curcuma longa, and Bupleurum chinense. Its proposed mechanisms of action involve reducing liver stiffness, inhibiting cuproptosis (copper-induced cell death), and regulating ferroptosis (iron-dependent cell death) by modulating the SLC7A11/GPX4 axis. Additionally, it has been shown to inhibit hepatic autophagy through the PI3K/Akt/mTOR pathway to alleviate liver damage. Research on this preparation has been conducted by institutions such as the First Affiliated Hospital of Anhui University of Chinese Medicine and Anhui University of Chinese Medicine.
- Other names
- gantou fumu肝豆扶木颗粒模拟剂肝豆扶木颗粒肝豆扶木汤
02
Targets
SLC7A11 (Cystine-Glutamate Antiporter)GPX4 (Glutathione peroxidase 4)mTOR (Mammalian target of rapamycin kinase)AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
Beyond the preview
Go deeper on Gandou Fumu Granule.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Gandou Fumu Granule.