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Ganluotong

Development stage: Phase 2
Lead developer: Sichuan Yatai Pharmaceutical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Ganluotong is a Traditional Chinese Medicine (TCM) therapeutic candidate developed by Sichuan Yatai Pharmaceutical Co., Ltd. It is primarily indicated for the treatment of portal hypertension in patients with chronic hepatitis B-related liver cirrhosis. Formulated as a chewing tablet, Ganluotong is intended to reduce portal vein pressure and improve liver function by addressing hepatic fibrosis and microcirculatory disturbances. Clinical development has reached Phase 2 in China, with trials such as CTR20140184 focusing on evaluating its safety, efficacy, and optimal dosing regimen in the target patient population.

Brand names: Ganluotong
Other names: Ganluotong Chewing Tablets肝络通肝络通咀嚼片

Targets

ET-1 (Endothelin-1)TGFB1 (Transforming growth factor Beta-1 proprotein)

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