Gannan Medical Univ. HDAC3 compound 8ae

Gannan Medical Univ. HDAC3 compound 8ae: sourced facts only. name: "We have designed and synthesized a series of novel hydrazide-based HDAC3 inhibitors, with the representative compound 8ae demonstrating potent HDAC3 inhibitory activity, having an IC50 value of 311 nM (with a selectivity index SI greater than 32 over other HDACs)." [PMID:40233424]; target: "We have designed and synthesized a series of novel hydrazide-based HDAC3 inhibitors, with the representative compound 8ae demonstrating potent HDAC3 inhibitory activity, having an IC50 value of 311 nM (with a selectivity index SI greater than 32 over other HDACs)." [PMID:40233424]; developer: "Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Disease, Ministry of Education, Jiangxi Provincial Key Laboratory of Tissue Engineering (2024SSY06291), College of Pharmacy, Gannan Medical University, Ganzhou, 314000, China." [PMID:40233424]; stage: "When combined with olaparib, 8ae significantly enhanced tumor suppressive activity (TGI = 88 %) in a breast cancer mouse model and displayed a favorable safety profile." [PMID:40233424]