ganoderic acid a

Ganoderic acid A is a triterpenoid compound found primarily in the fruiting bodies of Ganoderma lucidum and related species such as Ganoderma sinense and Wolfiporia cocos. It is one of the most abundant and well-studied triterpenoids in these medicinal mushrooms. Mechanistically, ganoderic acid A exhibits multiple biological activities including antinociceptive (pain-relieving), antioxidative, cytotoxic (anti-cancer), hepatoprotective (liver-protecting), and neuroprotective effects. Its anticancer activity has been linked to cytotoxicity against tumor cells and modulation of oxidative stress pathways. In preclinical studies it has shown potential for use in conditions such as cancer and Alzheimer's disease by reducing mitochondrial damage induced by amyloid-beta peptides[2][3][4][5]. The metabolism of ganoderic acid A involves extensive phase I and II biotransformation primarily via CYP3A isoenzymes[2]. It is not an approved pharmaceutical drug but is widely studied for its pharmacological properties.

Other names

Ganoderate ALanost-8-en-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7beta,15alpha,25R)-GANODERIC ACID A (USP-RS)GANODERIC ACID A [USP-RS]