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Garcinia mangostana pericarp extract
- Development stage
- Phase 2
- Lead developer
- Universitas Hasanuddin
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Garcinia mangostana pericarp extract is a botanical extract derived from the peel (pericarp) of the mangosteen fruit (*Garcinia mangostana*). It is rich in bioactive polyphenolic xanthones, primarily alpha-mangostin and beta-mangostin, which possess potent antioxidant, anti-inflammatory, and photoprotective properties. Developed as a topical gel formulation by Hasanuddin University, the extract is being clinically evaluated for its ability to prevent and treat narrowband ultraviolet B (NB-UVB)-induced skin redness (erythema) and hyperpigmentation in healthy adults. Its mechanism of action involves scavenging reactive oxygen species (ROS) and inhibiting inflammatory pathways, such as the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, thereby reducing the production of pro-inflammatory cytokines and prostaglandins.
- Other names
- Garcinia mangostana extractGarcinia mangostana pericarp gelmangosteen extractmangosteen pericarp extract
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HIF1A (Hypoxia-inducible factor 1-alpha)NF-κBPDCD1 (Programmed cell death protein 1 receptor)CD274 (Programmed cell death protein 1 ligand 1)STAT3 (Signal Transducer and Activator of Transcription 3)AcetylcholinesteraseAMY (Pancreatic alpha-amylase)Sucrase-Isomaltase
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