garlic oil macerate

Garlic oil macerate is a botanical extract produced by macerating crushed garlic cloves in vegetable oil (such as soybean or sunflower oil). This specific preparation method facilitates the chemical transformation of allicin into stable organosulfur compounds, most notably **ajoene** (E- and Z- isomers) and vinyldithiins. It is primarily recognized for its anti-inflammatory and anti-thrombotic properties. The mechanism of action involves the inhibition of the pro-inflammatory transcription factor **nuclear factor kappa B (NF-kB)** and the reduction of platelet activation, potentially through the modulation of fibrinogen binding to the **integrin alpha-IIb/beta-3 (GPIIb/IIIa)** receptor. Clinical research, such as trial NCT00275405, has investigated its effects on inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), and various adhesion molecules in healthy subjects.

Other names

garlic oil extractajoene-containing garlic oil