Drug intelligence / Profile preview

gastrodin benzyl alcohol ester

Development stage
Unknown
Lead developer
Beijing Kleb Pharmaceutical Development
Modality
Small Molecules
Administration
Oral
01

Overview

Gastrodin benzyl alcohol ester is a small molecule derivative of gastrodin, the primary bioactive constituent of the traditional Chinese medicinal herb *Gastrodia elata* Blume. Developed by Beijing Collab Pharmaceutical Development Co., Ltd., it is currently being investigated for the treatment of mild to moderate vascular dementia. As a modified version of gastrodin, this ester derivative is designed to enhance pharmacological activity and potentially improve blood-brain barrier penetration. Its mechanism of action involves neuroprotection through the modulation of GABAergic neurotransmission, reduction of oxidative stress, and inhibition of neuroinflammatory processes, which collectively aim to improve cognitive function and slow the progression of dementia symptoms.

Other names
天麻素苯甲醇酯
02

Targets

SSR (Succinate semialdehyde reductase)ABAT (4-aminobutyrate aminotransferase)SSADH (Succinate-semialdehyde dehydrogenase)

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