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GB-2001

Development stage: Preclinical
Lead developer: G2GBio
Modality: Nanoparticles → Drug Delivery Systems, Peptides
Administration: Subcutaneous, Intramuscular

Overview

GB-2001 is a long-acting veterinary drug candidate developed by G2G Bio for chemical castration in animals. It is formulated as a sustained-release injection using G2G Bio's proprietary InnoLAMP (Innovative Long-Acting MicroParticle) technology, which utilizes biodegradable polymer microspheres to provide a therapeutic duration of six months. The drug contains a gonadotropin-releasing hormone (GnRH) agonist, likely leuprolide acetate, which works by continuously stimulating the GnRH receptors in the pituitary gland. This continuous stimulation leads to receptor downregulation and a subsequent decrease in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), effectively suppressing the production of sex steroids (testosterone in males) to achieve non-surgical castration.

Other names: GB-2001 (6M)

Targets

GnRHR (Gonadotropin-releasing hormone receptor)

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